While previous literature has established an associationbetween sleep disruption and host response in infection, chronic sleepdeprivation, clock-disrupted individuals, including shift workers, orpatients with underlying circadian disorders are potentially at an increasedrisk of infection.65, 66, 67, 68 Regular orpermanent shift work and irregular or permanent night shifts have beencorrelated with SARS-CoV-2 positivity vs. controls.60 This evidence concerns the gene CLOCK and infection.