In contrast, 15-LOX protein levels were significantly higher in the CA1 (154%) (Wang et al., 2015), the mid-frontal (60%), and mid-temporal (55%) cortices (Pratico et al., 2004), but not in the cerebellum (Pratico et al., 2004) of post-mortem brains of patients with AD as compared to control (Fig. 4). The gene discussed is ALOX15; the disease is Alzheimer disease.