In order to evaluate the impact of DM on IFN-γ production upon Mycobacterium tuberculosis antigen stimulation during TB treatment, the plasma IFN-γ concentrations in response to TB1 and TB2 antigens were first measured with the QFT-P assay and compared between the TBP, TBDM, DM, and HC clinical groups. The gene discussed is REEP5; the disease is diabetes mellitus.