In a recent IMC study performed the skin lesions of SSc patients, authors identified additional subpopulations of fibroblasts with altered proportion in SSc skin compared to previous reports in the literature, including Thy1+; ADAM12high; PU.1high fibroblasts, ADAM12+;GLI1+ fibroblasts and TFAMhigh fibroblasts (54). Here, GLI1 is linked to systemic sclerosis.