In SLE and pSS compared to HD↑CD11c+ B cells, with:• CD21- CD38-↑Activation (CD69+, CD86+), proliferation (Ki67), prosurvival (CD137)↑ PD1, PDL1, CTLA4, ICOS, CD86. The gene discussed is ICOS; the disease is systemic lupus erythematosus.