In SSc:↓ CD56hi NK cells↓ IgD+ mB cells;↑ cMoIn SLE:↑ plasmablasts↓ IgM B cells;↓ IgD+ MBCs. In pSS:↓ IgM+ B cells.In pSS + SSc + SLE:↓ pDC. The gene discussed is CD40LG; the disease is systemic sclerosis.