GSEA pathway enrichment analysis showed that the expression of DRGs was closely associated with pathways including Head and Neck Squamous Cell Carcinoma, PI3K-Akt signaling pathway, focal adhesion, EGFEGFR signaling pathway, B cell receptor signaling pathway, TGF-beta signaling pathway, ERBB signaling pathway, VEGFR1 pathway, and Wnt signaling pathway (Figure 3E; Supplementary Table 3). The gene discussed is AKT1; the disease is head and neck squamous cell carcinoma.