PDCD1 and neoplasm: Finally, the antitumor mechanisms of high-dose AA in combination with anti-PD1 were comprehensively investigated through proteomic profiling of the tumor tissue of a mouse model, which indicated that high-dose AA exerted antitumor effects by regulating various immune-related mechanisms, including the B cell and T cell receptor signaling pathways, Fc gamma R-mediated phagocytosis, and NK cell-mediated cytotoxicity.