To determine the intercellular mechanisms driving T cell dysfunction in the DEN/CCl4 model, we first assessed the expression of immune regulatory molecules on LSEC (gated as CD45-CD146+CD31+PDPN-) (26, 46) among NPC from the livers of olive oil- or DEN/CCl4-treated mice. This evidence concerns the gene MCAM and nasopharyngeal carcinoma.