MiR-143-5p is significantly upregulated in M1-polarized bone marrow macrophage-derived exosomes (M1-BMDM-Exo) in high-fat-fed mice, promoting hepatocyte insulin resistance by targeting mitogen-activated protein kinase phosphatase-5 (MKP5), thereby reducing AKT and glycogen synthase kinase activation and glycogen production in hepatocytes (93). The gene discussed is DUSP10; the disease is Insulin resistance.