showed that macrophages transfer specific endogenous miRNAs (miR-142 and miR-233) into HCC cells in a cell contact-dependent manner, thereby influencing the post-transcriptional regulation of proteins in HCC, decreasing the expression of stathmin-1 (STMN1) and insulin-like growth factor-1 receptor (IGF-1R), and inhibiting HCC cell proliferation (23). The gene discussed is IGF1R; the disease is hepatocellular carcinoma.