M2-EVs protect against intestinal inflammation; they upregulate maternally expressed gene 3 (MEG3) by delivering lncRNA MEG3 to colonic epithelial cells, then promoting the transcription of CAMP responsive element binding protein 1 via competitive binding to miR-20b-5p, thereby enhancing cell viability and mitigating inflammatory response in UC (53). Here, MEG3 is linked to inflammation.