TLR4 and myocardial infarction: In a rat model of myocardial ischemia/reperfusion injury (MI/R), M2-Exos miR-148a are transported to cardiomyocytes and attenuates MI/R by downregulating thioredoxin-interacting protein (TXNIP) and inhibiting the TLR4/NF-κB/NLRP3 inflammasome signaling pathway (85).