MiR-29a and miR-210-5p are overexpressed in adipose tissue-derived exosomes and are delivered to adipocytes, muscle cells, and hepatocytes, mediating insulin signaling by targeting peroxisome proliferator-activated receptor-δ and SID1 transmembrane family member 2, respectively, thereby impairing glucose cellular uptake and inducing insulin resistance in vitro and in vivo (91, 92). Here, INS is linked to Insulin resistance.