METTL3 and thyroid gland carcinoma: showed that M2-EV miR-21-5p downregulated METTL3 expression in thyroid cancer cells, thereby leading to demethylation and stabilization of CD70 mRNA in a YTHDF2-dependent manner and that upregulation of CD70 protein levels increases the abundance of immunosuppressive Tregs and terminal failure T cells, thus promoting immunosuppressive and anti-PD-1 therapy resistance (157).