NLRP3 and diabetic kidney disease: analyzed the effect of HG-M-Exo on mouse podocyte cell lines and found that miR-21-5p increased the expression of inflammasome NLR family pyrin domain containing 3 (NLRP3), caspase-1, and IL-1β in podocytes by inhibiting anti-inflammatory factor A20, thus causing podocyte damage in diabetic nephropathy (104).