Afterwards, using the expression levels and regression coefficients of the five chosen prognostic-related genes, we computed the IGF2+ tumor cells score for each patient using the following formula: IGF2+ Tumor cells score = (0.094017867) × (CRYAB expression level) + (0.087558917) × (CTSD expression level) + (0.052475918) × (FOS expression level) + (0.046824215) × (SFRP1 expression level) + (0.044591224) × (IGF2 expression level). Here, CTSD is linked to neoplasm.