Recently, LL‐37 was identified as an endogenous agonist of chloride intracellular channel 1 and contributes to Alzheimer's disease progression29 Thus, the role of increased LL‐37 in the airways of BE patients with pathological airway dilation, especially those with P. aeruginosa infection, needs to be further studied. Here, CLIC1 is linked to Barrett esophagus.