The evidence presented here of increased MAPK3 (ERK1) phosphorylation on residues T202 and Y204 is consistent with previous human postmortem data showing enhanced MAPK3 phosphorylation at these sites within intraneuronal granular microstructures in the cortex of DLB patients62 and the SNpc of PD or DLB patients63. The gene discussed is MAPK3; the disease is Lewy body dementia.