Previous work by our group and others has described core spliceosome members, including U1-70K (snRNP70)22, 34, 95–97 and disordered RBPs such as G3BP1, TIA1, and SRRM2 in tau aggregation27, 57, 98, co-aggregating with tau in the cytoplasm across cellular57, murine models21, 47 and in human AD brain tissue22, 23, 96. Here, TIA1 is linked to Alzheimer disease.