By integrating with additional tau interactome studies and bulk brain proteomics, we show that the TauRD interactome provides shared insight into protein-protein interaction (PPI) changes, further reinforcing the role of RNA-binding proteins (RBPs) in AD and related Tauopathies17, 20, 21, 25, 30, 32–34, 56, 57, 80, 93. Here, SRRM2 is linked to Alzheimer disease.