To assess the disease relevance of our in vitro tau interactors to human brain tau interactors, our sTurbo TauRD interactors were compared to tau interactome datasets obtained from antibody-based AP-MS studies using Tau antibodies (Tau-5, total tau; PHF-1, phosphorylated pathological Tau, Supplemental Table 8) from AD frontal cortex15, 16. This evidence concerns the gene MAPT and Alzheimer disease.