HLA-G and gastrointestinal disease: One gene that exhibited striking differences in colocalization between the GTEx and AA eQTL datasets is HLA-G, an immune checkpoint molecule that has been implicated in gastrointestinal disease, diabetes, and adverse pregnancy outcomes such as preeclampsia.31, 32, 33 61 meSNPs exhibited colocalization with the GTEx dataset, while 35 meSNPs exhibited colocalization with the AA dataset.