We identified two meCpG-eGene pairs of interest that are associated with Type 1 Diabetes (T1D), a disease whose prevalence is increasing in ethnic minorities such as African Americans.36 The first meCpG, cg00030291, was found to mediate the effect of rs3779356 on the expression ICA1, a gene whose hypermethylation and differential expression have been previously linked to diabetes.37 This SNP was colocalized only with the GTEx dataset, as this was not a significant eQTL in the AA eQTL dataset. This evidence concerns the gene ICA1 and type 1 diabetes mellitus.