INS and obesity due to melanocortin 4 receptor deficiency: Glyoxalase 1 (Glo1) has been linked to obesity[1] [1, 2], glycemic control [3], insulin sensitivity [4], aortic endothelial cell dysfunction [5], non-alcoholic fatty liver disease (NAFLD) [6], skeletal muscle dysfunction [7] and CVD [8], suggesting its importance in regulating metabolic health [9, 10].