Common variants in LMX1B are associated with IOP variation and the most common form of human glaucoma, primary open-angle glaucoma (POAG).24–29 Rare Mendelian variants in LMX1B can produce early-onset ocular hypertension and open-angle glaucoma (OAG).30 We have previously demonstrated that mice with a dominant mutation in Lmx1b (Lmx1bV265D/+) develop IOP elevation and glaucoma.30,31 Depending on the genetic background, this Lmx1bV265D mutation induces either early-onset or later glaucoma31. Here, LMX1B is linked to open-angle glaucoma.