The 5 genes with the largest hyper-AF areas were BEST1, CDH23, NR2E3, MYO7A, and RDH12, with mean areas of 0.50, 0.47, 0.44, 0.38, and 0.33 mm2, respectively (Fig 4B). This evidence concerns the gene NR2E3 and atrial fibrillation.