Analyzing associations between identified features and genes across most common genes (Table S5, available at www.ophthalmologyscience.org), the 5 genes with the largest hypo-AF areas at first presentation were CHM, ABCC6, RDH12, ABCA4, and RPE65, with mean per-patient areas of 43.72, 29.57, 20.07, 19.65, and 16.92 mm2, respectively (Fig 4A). This evidence concerns the gene RPE65 and atrial fibrillation.