Across patients at presentation, the 5 genes with the largest hypo-AF areas were CHM, ABCC6, RDH12, ABCA4, and RPE65, with mean per-patient areas of 43.72, 29.57, 20.07, 19.65, and 16.92 mm2, respectively. The gene discussed is ABCC6; the disease is atrial fibrillation.