For hyper-AF, BEST1 exhibited the largest areas of hyper-AF, which can be attributed to the vitelliform lesion(s) that are characteristically observed in autosomal dominant and recessive forms of the disease (Fig 4B).37, 38, 39 For ring, the presence of a macular ring typically corresponds to a demarcation between the diseased and nondiseased retina and is usually seen in RP and cone–rod dystrophies, in keeping with our findings here (Fig 4C).3 Here, BEST1 is linked to retinitis pigmentosa 1.