miR-let-7c acts as a cancer suppressor in a variety of ways, including preventing early cancer progression by suppressing Hmga2 expression [56], inhibiting migration and invasion of human non-small cell lung cancer and colorectal cancer [57,58], and inducing cell apoptosis and disrupting the cell cycle in human hepatocellular carcinoma cells. The gene discussed is HMGA2; the disease is non-small cell lung carcinoma.