BDNF and hepatocellular carcinoma: Moderated mediation analysis confirmed that training assignment moderated the mediation of the linear effect of time point on BDNF via concurrently reduced HCC in that mediation was significant in the training cohorts (ACME: 0.020 [95% CI, 0.001 to 0.04], p = .036, 11.6% of total effect) but not in the control cohort (ACME: 0.007 [95% CI, −0.01 to 0.03], p > .35, 3.6%) (82).