BDNF and hepatocellular carcinoma: Lagged mediation analysis further supported an indirect effect of training duration on BDNF at T2 and T3 via HCC reduction at the preceding time points (T1 and T2, respectively) (14.4% mediation; ACME: 0.046 [95% CI, 0.003 to 0.10], p = .037, 233 observations from 134 participants) (see Figure 3C2).