TRPV1 and Pain: It is a constituent of more than 300 enzymes involved in cell replication, protein synthesis, and injury repair systems and is also known to have anti-inflammatory effects.8 Zinc is also implicated in neuropathic pain and thermal hyperalgesia, with there being sporadic reports of it exacerbating or alleviating symptoms in a dose-dependent manner.9–12 Research has suggested that zinc may have a significant effect on CIPN and neuropathic pain through the function of transient receptor potential vanilloid 1 (TRPV1), which is a capsaicin receptor.