NR3C2 and chronic kidney disease: The prevalence of CKD before adrenalectomy was 27.8% in this study, which is higher than that in other reports.1,14 Treatment with MR antagonists has been reported to decrease the eGFR similarly to adrenalectomy in patients with PA.18 Although the effect of including 15 (27.8%) patients who had received preoperative medical therapy with MR antagonists to compare pre- and post-adrenalectomy should be considered, our findings suggested that the presence or absence of treatment with MR antagonists was not a significant factor associated with a certain drop in eGFR.