CALR and systemic lupus erythematosus: While associations between clinical phenotypes in DR7h were not seen in this cohort, others reported associations with predominantly cutaneous presentation [46,47], and specific autoantibody patterns including anti-Smith (Sm), anti-SSA/Ro, and anti-cardiolipin autoantibody positivity in adult-onset SLE cohorts [[48], [49], [50]].