TP53 and neoplasm: Furthermore, we discounted the possibility that the emergence of a CSC-like state in DAOY cells was caused by the TP53 mutation because of the prevalence of a CSC-like state in patient SHH-MB analyzed here that were wild type for TP53 (Figure 4A, C and Supplementary Figure S7B—F) and the expression of NSC markers in ONS-76 cells in tumor spheroid-organoid co-culture (Supplementary Figure S5F).