Cutaneous leiomyomas (CLMs) are associated with Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) syndrome (Mendelian Inheritance in Man [MIM]: 150800)—a rare genodermatosis caused by a heterozygous pathogenic variant in the fumarate hydratase (FH) gene. The gene discussed is FH; the disease is Cutaneous leiomyoma.