SVEP1 and heart failure: A second coding variant, rs61751937 (p.R229G) is associated with increased platelet reactivity [6], reduced platelet count (PC) and increased mean platelet volume (MPV) [6], open-angle glaucoma [7], and exerts the strongest effect on SVEP1 plasma levels [[3], [4], [5]], Elevated levels of plasma SVEP1 have been found to associate with several chronic age-related diseases, including aging [8,9], glaucoma [7], pulmonary hypertension [10], incident CAD [5,11] heart failure [11], atrial fibrillation [12], and dementia [13].