Conversely, elevated KANK2 mRNA expression was noted in cholangiocarcinoma (CHOL), glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC), and pancreatic adenocarcinoma (PAAD) (p < 0.001), with significance in HNSC at p < 0.01. Here, KANK2 is linked to head and neck squamous cell carcinoma.