IL2 and cancer: Moreover, the glycogen riskScore signature was significantly positively related with IL2-STAT5 signaling, coagulation, angiogenesis, inflammatory response, epithelial mesenchymal transition, myogenesis, NOTCH signaling, TGF beta signaling, WNT beta catenin signaling and hypoxia across pan-cancer, which are important pathways that occur in TME to promote development and progression of cancer.