Zeste homolog 2 enhancer (EZH2), an oncogene that is overexpressed in various human cancers, is a subunit of polycomb inhibitory complex 2 (PRC2), which binds to approximately 20% of lncRNAs and catalyzes H3K27 trimethylase activity through lncRNAs 20, 21. The gene discussed is EZH2; the disease is cancer.