Interestingly, TRPV4 activation in NPC cells with high-stiffnesss condition under enhanced ROS production (Fig. 5A-B), while pharmacological inhibition of TRPV4 (HC067047) or NOX (apocynin) suppressed GSK1016790A-induced ROS production (Fig. 5A-B), indicating that TRPV4 may regulate ROS levels through NOX. Here, TRPV4 is linked to nasopharyngeal carcinoma.