As indicated in Fig. 3C, tumor cells of the C0 group enriched in TGF-β signaling and angiogenesis, G2M checkpoint, tumor cells of the C2 group enriched in hedgehog signaling, KRAS signaling, and G2M checkpoint, tumor cells of the C3 group enriched in epithelial-mesenchymal transition (EMT). Here, TGFB1 is linked to neoplasm.