GMDP signals through NOD2 on myeloid cells to release IL-1b and NLRP3 to induce cytotoxic granzyme B+CD8+ T cells in the tumor and enhances the efficacy of anti–CTLA-4, anti–PD-1, and anti–PD-L1 in different mouse tumor models (7). Here, NLRP3 is linked to neoplasm.