Strikingly, most of the Wnt genes upregulated by HMGA1 in our murine model are also upregulated in human colon cancer, including the WNT effectors, ASCL2, AXIN2, CTNNB1, MYC, EPHB2, CD44, and ETS2 and the WNT receptors, LGR5, LRP5, and LRP6 (Figure 11, C and D). This evidence concerns the gene LRP5 and colonic neoplasm.