Intragastric administration of IL10-producing Lactococcus lactis also protects mice from DSS-induced colitis and can prevent the development of spontaneous colitis in IL10-deficient mice (52), and Helicobacter hepaticus and Bacteroides fragilis polysaccharides can induce IL-10 production from gut-resident MNPs and T cells (53, 54). The gene discussed is IL10; the disease is colitis.