The research indicates that [67Cu]-NOTA-PEG2Nle-CycMSHhexSPECT and [64Cu]-NOTA-PEG2Nle-CycMSHhex PET exhibited favorabletumor targeting and biodistribution characteristics, which highlighttheir potential as MC1R-targeted therapeutic peptides for the treatmentof melanoma.182,184. The gene discussed is MC1R; the disease is melanoma.