CCL2 and obesity due to melanocortin 4 receptor deficiency: Previous studies have shown thatenhanced PPARγ expression leads to lipid accumulation in theliver of patients with nonalcoholic fatty liver disease.2,3 In liver and adipose tissue, increasing ACC1 results in triglycerideaccumulation.4,5 FAS in adipocytes is associatedwith obesity-induced insulin resistance, steatosis of liver and adiposetissue inflammation with the secretion of pro-inflammatory cytokinessuch as IL-1α, IL-1β, IL-6, IL-8, and MCP-1.6,7