Adipose tissue functions as an active endocrineand immune organ,regulating inflammation through the production of fatty acid-bindingproteins, adipokines, leptin, and lipid droplet-associated proteins.Obesity is often accompanied by chronic inflammation, with adiposetissue secreting various pro-inflammatory factors such as MCP-1, TNF-α,IL-1β, and IL-6. Here, PLIN1 is linked to obesity due to melanocortin 4 receptor deficiency.