The NFkB transcription factor plays a central role in the regulation of inflammation and has already been described to participate in the development of EAE and MS (Jia et al. 2011), suggesting that the TAK1‐dependent IKK and NF‐kappa‐B activation pathway might be in part responsible for the worsening of EAE with aging. The gene discussed is NFKB1; the disease is myeloid sarcoma.