We identified 10 enriched transcription factors in the first phase of the disease with age, of which Trp53, Smad3, Mecp2, Bcl6, Tcf4, and Stat3 have already been described to be involved in the peripheral immune response of MS patients (Ahmad et al. 2022; Asashima et al. 2022; Deng et al. 2005; Horjus et al. 2022; Li et al. 2020; Li et al. 2019). The gene discussed is SMAD3; the disease is myeloid sarcoma.