For example, C1GALT1 has been shown to promote cancer by O-glycosylating receptor tyrosine kinases, such as EGFR in head and neck squamous carcinoma16 and prostate cancer19, FGFR in colorectal cancer21 and EPHA2 in gastric adenocarcinoma15, resulting in inhibition of these oncogenic signaling pathways. This evidence concerns the gene EPHA2 and cancer.