C1GALT1 overexpression has been documented in various malignancies, including pancreatic, esophageal, gastric, colorectal, ovarian, prostate, liver, lung, and head and neck cancers, and shown to contribute to the malignant phenotype (e.g., cell migration, proliferation, and metastasis) and chemotherapeutic drug resistance15–25. The gene discussed is C1GALT1; the disease is head and neck cancer.