Furthermore, the ability of ITZ to suppress the growth of TC-71 or TC-32 xenografts was comparable to that observed upon knockdown of C1GALT1, and was not further exacerbated by C1GALT1 knockdown (Fig. 7f and Supplementary Fig. 12f), indicating that ITZ exerts its effects on ES tumor growth by inhibiting C1GALT1. This evidence concerns the gene C1GALT1 and Ewing sarcoma.