Zinc was found to bind with SFPQ, a ubiquitous nuclear RNA-binding protein, and induce infinite polymerization of SFPQ in primary cortical neurons.563 Aggregation of FUS protein is another hallmark of ALS.564 Zinc could enhance liquid-liquid phase separation of FUS protein and promote its aggregation.565. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.