In the high-iron and PD mice models, knockout of the transcription factor NF-E2-related factor 2 (Nrf2) prevented iron deposition in the SN and striatum.206 The mechanism is likely achieved by decreasing the level of FPN1 on microvascular endothelial cells, which hinders the process of iron entry into the brain. This evidence concerns the gene NFE2L2 and Parkinson disease.