ATP13A2 and dementia: PARK9, encoded by the ATP13A2 gene, is abundantly expressed in nigral dopaminergic neurons, and mutations within ATP13A2 can cause hereditary Parkinsonism with dementia.522 Deficiency in ATP13A2 results in dysregulation of lysosomes and aggregation of α-synuclein,523 possibly due to zinc dyshomeostasis.524,525