Additionally, activating Nrf2 could also improve neurodegeneration in the SOD1G93A mice model of ALS.382 Decreased Speedy/RINGO cell cycle regulator family member A (SPY1), which was caused by MDM2-mediated ubiquitination degradation, was also involved in ferroptosis in the SOD1G93A mice, and overexpression of SPY1 could inhibit ferroptosis by regulating GCH1/BH4 axis and TfR1, thereby delaying the occurrence and prolonging the survival SOD1G93A mice.383. The gene discussed is SPDYA; the disease is amyotrophic lateral sclerosis.