LRRK2 and Parkinson disease: In iPSC-derived microglia from PD patients carrying LRRK2-G2019S, Tf recycling was found to be dysregulated under proinflammatory conditions, and this dysregulation was observed in the lysosomes located near the nucleus.290 Additionally, both iron and ferritin accumulation were found in the inflammatory microglia of LRRK2-G2019S knock-in mice.290 Microglia can interact directly with α-synuclein, thereby promoting the occurrence and development of PD.