A high level of labile zinc was observed in the neurons and astrocytes in the spinal cords of SOD1G93A mice, which may be due to increased HNE levels.547 The native SOD1 protein is expressed as a homodimer in the cytosol, capable of binding with either four copper or four zinc ions.548 However, mutations in SOD1 impair dimerization and promotes its aggregation in ALS.549 Zinc can stabilize the native structure of the SOD1 monomer and promote its homo-dimerization. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.