SLC40A1 and Parkinson disease: In the 6-OHDA-induced PD rat model, acupuncture was found to reduce iron accumulation in the SN by balancing the ratio of DMT1/FPN1, thereby protecting nigral dopaminergic neurons.275 In PC12 cells, aspirin has been reported to increase the expression of FPN1 by inhibiting hepcidin through the IL-6/JAK/STAT3 pathway, which promotes FPN1-mediated iron release and reduces neuronal iron levels.276 All these evidences suggest that modulating FPN1 is promising manner to reduce iron level in nigral dopaminergic neurons.