In the 6-OHDA-induced PD rat model, acupuncture was found to reduce iron accumulation in the SN by balancing the ratio of DMT1/FPN1, thereby protecting nigral dopaminergic neurons.275 In PC12 cells, aspirin has been reported to increase the expression of FPN1 by inhibiting hepcidin through the IL-6/JAK/STAT3 pathway, which promotes FPN1-mediated iron release and reduces neuronal iron levels.276 All these evidences suggest that modulating FPN1 is promising manner to reduce iron level in nigral dopaminergic neurons. The gene discussed is SLC11A2; the disease is Parkinson disease.