HAMP and Parkinson disease: Astrocytes have attracted increasing attention in PD.298 In both rotenone- and 6-OHDA-induced PD mice, overexpression of hepcidin using a virus-based strategy has been found to suppress major pathologies of parkinsonism and motor deficits,299 suggesting that further studies could explore the protective role of astrocyte-derived hepcidin in PD.