Therefore, the above results suggest that EA treatment might regulate lncRNA-XR_002789763.1/miR-342-5p axis and activate the mitophagy-related PINK1/Parkin signaling pathway, and promote Mfn2 ubiquitination, thereby reducing RGC damage and delaying myopia progression in guinea pigs (Fig. 8). This evidence concerns the gene MFN2 and myopia.