CDH1 and colorectal carcinoma: It has been emerged also as a critical candidate for CRC predisposition due to its ability to bind to E-cadherin on the surface of colon cells via FadA adhesion, activating the Wnt/B-catenin signaling pathway and producing an inflammatory and oncogenic response, as well as its capacity to bind to the inhibitory immune receptor via Fap2 adhesin, altering natural killer cells [53].