To support the aforementioned findings, a recent study found that the AhR/IL-22/Stat3 signaling pathway is used by commensal microbiota to modify antimicrobial peptides in the intestinal mucosa.62 Collectively, our research reveals that AhR activation via I3C therapy in colitis mice transcriptionally increases α-defensin 1, reversing microbial dysbiosis as demonstrated by an increase in Firmicutes and Virrucomicroiota bacteria and a decrease in gram-negative bacteria, ultimately suppressing colitis. This evidence concerns the gene STAT3 and colitis.