It has been reported that the loss of the AhR enhances colitis development, and AhR activation has been shown to prevent colitis.6,29,30 Our findings consistently found that AhR activation by I3C was positively correlated with the induction of α-defensin 1 in ileal epithelial cells from control and mice with TNBS- (Figures 2e,f and h), DSS- (Figures 2i,j,l) and anti-CD40 (Figures 2m,n and p)-induced mice models. Here, CD40 is linked to colitis.