MRTFA and Hepatic fibrosis: It is suggested to be involved in hepatic fibrosis through the binding of integrins and ECM ligands and focal adhesion proteins, which further activates several actins and ultimately allows nuclear translocation of myocardin-related transcription factor A. The interaction between myocardin-related transcription factor A and serum-response factor with regulatory elements is crucial in controlling the differentiation of myofibroblasts and the synthesis of ECM; it also plays an important role in cytoskeletal function in hematopoietic stem cells, potentially leading to fibrogenesis (41).