Our previous study showed that NMN administration alleviated CORT-induced depression-like behavior and is associated with that NMN supplementation increased NAD+ levels to enhance SIRT3 activity [46], [47], [48], which is similar to the findings that resveratrol rescued chronic unpredictable mild stress-induced depression-like behavior [49] and kaempferol exhibited the antidepressant effect [50] through activating SIRT3 related pathways. This evidence concerns the gene SIRT3 and major depressive disorder.