Most importantly, in the study of ccRCC, we have confirmed that the highly expressed SIRT2 can interact with G6PD, facilitate its activity through deacetylation, and increase its stability by reducing ubiquitination and enhancing SUMO1 modification, leading to an increase in G6PD activity and tumorigenesis in ccRCC (19). Here, G6PD is linked to nonpapillary renal cell carcinoma.