CCNE1 and nonpapillary renal cell carcinoma: As expected, cell cycle regulatory factors such as CyclinD1, CDK4, CDK6, CyclinE1, and CDK2, which are known to play a pivotal role in the pathogenesis of ccRCC (6, 16), were greatly reduced at both mRNA and protein levels following BANCR OE in ACHN and 786-O cells.