β-HCH was positively associated with inflammatory markers (log-hsCRP: adj-β = 0.11, 95 %CrI: 0.03, 0.19; log-IL-6: adj-β = 0.08, 95 %CrI: 0.03, 0.14).<h4>Conclusion</h4>With over a decade of follow-up, we extend evidence on previously reported associations of DDT and β-HCH with several measures of obesity. Here, IL6 is linked to obesity due to melanocortin 4 receptor deficiency.