Furthermore, NCGA treatmentreduced the expression of p-p38/p38 and activity of caspase 3 to agreater degree, implying stronger inhibition of the proapoptotic pathways.Notably, NCGA treatment reduced the levels of α-synuclein andAβ, two proteins implicated in the pathogenesis of PD and AD,respectively, in a more significant manner compared with that of CGA.These results suggest that NCGA may be more potent in modulating certainkey pathways involved in neurodegeneration. This evidence concerns the gene CASP3 and Parkinson disease.