In our study, the observed lenticule changes, increased lens density (patient 10) and punctate lens opacities in the periphery (patients 09 and 24), appeared to be non-specific for PRL-related issues, as anterior subcapsular cataract was considered the most common type of posterior chamber pIOL-induced cataract [35, 43], and patient-dependent factors such as age (ages 43–46 years) and refractive status (− 14.0 D to − 22.75 D) may also play a role [34, 35, 43]. This evidence concerns the gene PRL and cataract.