HAVCR2 and neoplasm: Furthermore, in a murine model, Tim-3, an inhibitory receptor, was found to be upregulated in tumor-infiltrating LrNK cells, which could dampen the anti-tumor effect of LrNK cells by inhibiting the phosphatidylin-ositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway [46].