In mouse models of lymphocytic choriomeningitis virus (LCMV) and adenovirus infection, LrNK cells inhibited the antiviral activity of virus-specific T cells through the programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) axes [47] (Fig. 1a). The gene discussed is CD274; the disease is adenoviridae infectious disease.