IDH3A and central nervous system cancer: In order to detail PTPRZ1 at cellular resolution, we interrogated publicly available glioblastoma and isocitrate dehydrogenase (IDH)-mutant glioma single-cell RNA-seq (scRNA-seq) datasets40,41, and found PTPRZ1 to be highly expressed in malignant cells but not in immune cells such as T cells and macrophages, nor in normal glial cells, oligodendrocytes and microglia (Fig. 1b, Supplementary Fig. 1d-h).