Indeed, in the first five hours, PTPRZ11814-1822 TCR-T cells preferentially killed SCCs while after 24 h, both SCCs and FCCs were lysed (Fig. 5c, Supplementary Fig. 10c), suggesting a preferential anti-tumor activity on stem-like SCCs by PTPRZ1-TCR-T. This evidence concerns the gene PTPRZ1 and neoplasm.