Moreover, additional irradiation of tumor cells in vitro resulted in increased lysis of target cells likely due to enhanced activation of PTPRZ1-TCR-CD4+-T but not PTPRZ1-TCR-CD8+-T (Fig. 3d, e, Supplementary Fig. 5e–h and Supplementary Fig. 6c–f). This evidence concerns the gene PTPRZ1 and neoplasm.