The relevance of these findings to human disease was supported by the observation of reduced miR-142 levels (Supplementary Fig. 1a) and increased PDCD1 (PD-1) and CTLA-4 mRNA expression (by RT-PCR; Supplementary Fig. 15g), along with increased membrane surface levels of PD-1 and TIM-3 proteins (by flow cytometry analysis; Supplementary Fig. 15h–j), in T cells from BC CML patients compared with those from CP CML patients. This evidence concerns the gene HAVCR2 and breast cancer.