To this end, T cells from BC CML patients had, in addition to lower miR-142 levels (Supplementary Fig. 1a), reduced cytokine production (i.e., IFNγ and IL-2; Fig. 3d), reduced frequencies of naïve T cells (CD3+ CD45RA+ CCR7+), increased frequencies of effector T cells (CD3+ CD45RA+ CCR7−) (Fig. 3e), and increased rates of spontaneous apoptosis [mainly in effector and effector memory (CD3+ CD45RA−CCR7−) T subtypes; Fig. 3f; Supplementary Fig. 9e], compared with T cells isolated from CP CML patients. This evidence concerns the gene CCR7 and chronic myelogenous leukemia, BCR-ABL1 positive.