Five in vivo models were employed to represent different disease scenarios: the CD33+CD1d+ THP1-FG and KG1-FG xenograft mouse models (Fig. 5a–n), the CD33+CD1dlo/- HL60-FG xenograft mouse model (Supplementary Fig. 8a–d), the CD33-CD1d+ THP1-FGCD33-/- xenograft mouse model (Supplementary Fig. 8e–h), and an AML PDX mouse model (Fig. 6). Here, GLI2 is linked to acute myeloid leukemia.